TABLE 2.
The 10 erm(39) gene sequevar types identified in M. fortuitum
| Sequevar | No. of isolates | Susceptibility to CLRa | Nucleotide (amino acid)b
at the following base pair position (corresponding amino acid amino acid position): |
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| T11 (V4) | G19 (G7) | G64 (V22) | GTG 76-78 (V26) | G97 (A33) | G101 (G34) | A235 (I79) | G358 (A120) | T362 (I121) | C536 (A179) | G563 (R188) | G619 (A207) | G661 (A221) | C676 (P226) | G707 (R236) | T729 (D243) | |||
| 1c | 0 | • | • | • | • | • | • | • | • | • | • | • | • | • | • | • | • | |
| 2 | 1 | IR | • | • | • | • | • | • | • | T (S) | • | • | • | • | • | • | • | • |
| 3d | 34 | IR | • | • | • | • | A (T) | • | G (V) | • | • | • | • | • | • | • | • | • |
| 4e | 1 | IR | C (A) | • | A (I) | • | A (T) | • | G (V) | • | • | • | • | • | • | • | • | • |
| 5 | 1 | IR | • | • | • | • | A (T) | • | G (V) | • | • | • | • | • | • | A (T) | • | • |
| 6 | 1 | Susceptible | • | A (S) | • | • | A (T) | • | G (V) | • | • | • | • | • | • | • | • | • |
| 7 | 1 | Susceptible | C (A) | • | • | • | A (T) | C (A) | G (V) | • | • | • | • | • | • | • | • | • |
| 8 | 3 | Resistant | C (A) | • | • | ATC (I) | A (T) | • | G (V) | • | • | • | • | • | A (T) | • | A (Q) | A (E) |
| 9 | 1 | Resistant | C (A) | • | • | ATC (I) | A (T) | • | G (V) | • | • | A (D) | • | A (T) | A (T) | • | A (Q) | A (E) |
| 10 | 1 | Resistant | C (A) | • | • | ATC (I) | A (T) | • | G (V) | • | C (T) | • | A (H) | • | A (T) | • | A (Q) | A (E) |
a
Abbreviations: CLR, clarithromycin; IR, inducibly resistant.
b
Nucleotides (amino acids) for sequevar type 1 are shown in the column subheads. •, identical nucleotides. For altered nucleotides, the corresponding amino acid change is also indicated.
c
Type strain DSM46621.
d
Identical to the sequence of strain CT6.
e
This isolate had the additional substitutions L99V, K156R, S158P, T174I, and P212S.