TABLE 1.
β-Lactamase-encoding genes detected among ceftazidime-resistant baseline pathogens recovered from patients enrolled in both arms of the ceftazidime-avibactam phase 3 triale
| Pathogen (no.; % of total) | β-Lactam class(es)a | Result(s)a | No. of isolates |
|---|---|---|---|
| E. coli (123; 40.7) | A, D | CTX-M-15; OXA-1 | 44 |
| A | CTX-M-15; TEM-1 | 25 | |
| A, D | CTX-M-15; OXA-1; TEM-1 | 12 | |
| A | CTX-M-15 | 10 | |
| A | CTX-M-27 | 5 | |
| A, C | CMY-2; TEM-1 | 5 | |
| A, C, D | CTX-M-15; CMY-2; OXA-1; TEM-1 | 4 | |
| A | CTX-M-27; TEM-1 | 2 | |
| A | CTX-M-55 | 2 | |
| A, C, D | CTX-M-15; CMY-42; OXA-1 | 2 | |
| A | CTX-M-1 | 1 | |
| A | CTX-M-14 | 1 | |
| A | CTX-M-15; CTX-M-3; TEM-1 | 1 | |
| A | CTX-M-2 | 1 | |
| A | CTX-M-32 | 1 | |
| A, C | DHA-1; SHV-12; TEM-1 | 1 | |
| A, D | CTX-M-14; CTX-M-15; OXA-1 | 1 | |
| A, D | CTX-M-15; CTX-M-27; OXA-1; TEM-1 | 1 | |
| A, D | CTX-M-15; CTX-M-3; OXA-1 | 1 | |
| A, D | CTX-M-15; OXA-1; TEM-33 | 1 | |
| A, D | CTX-M-3; OXA-1 | 1 | |
| C | ACT-24 | 1 | |
| K. pneumoniae (125; 41.4) | A, D | CTX-M-15; OXA-1; SHV-1; TEM-1 | 37 |
| A, D | CTX-M-15; OXA-1; SHV-11; TEM-1 | 27 | |
| A, D | CTX-M-15; OXA-1; SHV-1 | 7 | |
| A | CTX-M-15; SHV-1; TEM-1 | 6 | |
| A, D | CTX-M-15; OXA-1; SHV-11 | 5 | |
| A, D | CTX-M-15; OXA-10; SHV-1; TEM-1 | 4 | |
| A | CTX-M-15; SHV-1 | 3 | |
| A | CTX-M-15; CTX-M-3; SHV-1; TEM-1 | 3 | |
| A | CTX-M-15; SHV-11; TEM-1 | 2 | |
| A | CTX-M-3; SHV-11 | 2 | |
| A | KPC-3; SHV-11 | 2 | |
| A | KPC-3; SHV-11; TEM-1 | 2 | |
| A, D | CTX-M-15; OXA-1; OXA-48; SHV-11 | 2 | |
| A, D | OXA-2; SHV-18 | 2 | |
| A | CTX-M-15; CTX-M-3; TEM-1 | 1 | |
| A | CTX-M-15; SHV-11; SHV-12; TEM-1 | 1 | |
| A | CTX-M-15; SHV-38; TEM-1 | 1 | |
| A | CTX-M-2; SHV-11; TEM-1 | 1 | |
| A | CTX-M-3; SHV-11; SHV-2; TEM-1 | 1 | |
| A | CTX-M-3; SHV-11; TEM-1 | 1 | |
| A | KPC-2; SHV-11; TEM-1 | 1 | |
| A | SHV-5 | 1 | |
| A, B | NDM-1; SHV-11 | 1 | |
| A, B | SHV-11; TEM-1; VIM-4 | 1 | |
| A, C | CMY-4; CTX-M-15; SHV-1 | 1 | |
| A, C, D | CMY-4; CTX-M-15; OXA-1; SHV-1 | 1 | |
| A, C, D | CTX-M-15; DHA-1; OXA-1; SHV-11; TEM-1 | 1 | |
| A, D | CTX-M-15; CTX-M-3; OXA-1; SHV-1; TEM-1 | 1 | |
| A, D | CTX-M-15; KPC-2; OXA-1; SHV-1; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1; OXA-48; SHV-1; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1; SHV-1; SHV-11; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1; SHV-1; SHV-5; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1; SHV-38; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-9; SHV-1; TEM-1 | 1 | |
| A, D | OXA-9; SHV-11; TEM-1 | 1 | |
| Enterobacter spp. (17; 5.6)b | A, C, D | CTX-M-15; cAmpC; OXA-1; TEM-1 | 5 |
| C | cAmpC | 3 | |
| A | CTX-M-15 | 1 | |
| A, B, D | CTX-M-15; NDM-1; OXA-1; TEM-1 | 1 | |
| A, C | CTX-M-15; cAmpC | 1 | |
| A, C | CTX-M-3; cAmpC; TEM-1 | 1 | |
| A, C, D | CTX-M-15; CTX-M-3; cAmpC; OXA-1; TEM-1 | 1 | |
| A, C, D | CTX-M-15; cAmpC; OXA-1 | 1 | |
| A, C, D | cAmpC; OXA-1; SHV-12; TEM-1 | 1 | |
| A, D | CTX-M-15; CTX-M-3; OXA-1; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1 | 1 | |
| C. freundii (7; 2.3) | A, C | cAmpC; TEM-1 | 1 |
| A, C, D | CMY-86; CTX-M-15; OXA-1; TEM-1 | 1 | |
| A, C, D | CTX-M-15; CTX-M-3; cAmpC; OXA-1 | 1 | |
| A, C, D | CTX-M-15; cAmpC; OXA-1; TEM-1 | 1 | |
| A, D | CTX-M-15; OXA-1; TEM-1 | 1 | |
| A, C | CTX-M-15; cAmpC; DHA-4; TEM-1 | 1 | |
| C | cAmpC | 1 | |
| P. mirabilis (6; 2.0) | A | TEM-1; VEB-6 | 1 |
| A, B, C | CMY-16; SHV-12; TEM-1; VIM-1 | 1 | |
| A, C | ACC-4; TEM-1 | 1 | |
| A, C | CMY-16; TEM-1 | 1 | |
| A, D | CTX-M-3; OXA-9; SHV-5; TEM-1 | 1 | |
| C | CMY-16 | 1 | |
| K. oxytoca (2; 0.7) | A, D | CTX-M-15; OXA-1; TEM-1 | 1 |
| A, D | CTX-M-15; OXA-9; TEM-15 | 1 | |
| Providencia spp. (2; 0.7)c | A, B | CTX-M-3; NDM-1; TEM-1 | 1 |
| A, C | ACC-4; TEM-1 | 1 | |
| S. marcescens (2; 0.7) | A, C, D | CMY-4; CTX-M-15; OXA-1; TEM-1 | 1 |
| A, D | CTX-M-15; CTX-M-3; OXA-1; TEM-1 | 1 | |
| P. aeruginosa (18; 6.0) | C | cAmpC | 5 |
| A, D | OXA-10; VEB-9 | 3 | |
| A, D | OXA-2; OXA-74d ; PER-1 | 2 | |
| A, D | OXA-2; PER-1 | 2 | |
| A, C, D | cAmpC; OXA-10; VEB-9 | 1 | |
| A, D | OXA-10; VEB-1 | 1 | |
| A, D | OXA-74d ; PER-1 | 1 | |
| B | VIM-2 | 1 | |
| C, D | cAmpC; OXA-17d | 1 | |
| C, D | cAmpC; OXA-2 | 1 | |
a
Molecular class according to Bush and Jacoby (26). cAmpC represents overexpression of the intrinsic chromosomal ampC gene according to reverse transcription-quantitative PCR (qRT-PCR) experiments.
b
Includes 16 E. cloacae and 1 Enterobacter aerogenes isolate.
c
Includes 1 P. rettgeri and 1 P. stuartii isolate.
d
OXA-10-like enzymes.
e
Note that five patients had 2 pathogens at the baseline visit.