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. 2019 May 23;63(6):e02655-18. doi: 10.1128/AAC.02655-18

TABLE 4.

Patients with baseline isolates who presented an unfavorable microbiological response or had an indeterminate status at TOCa

Arm and pathogen Country Infection CAZ-AVI MIC (μg/ml) Molecular characterization
CAZ-AVI
    C. freundii Bulgaria cUTI 0.5 CTX-M-15; OXA-1; TEM-1
    E. cloacae Bulgaria cUTI 2 cAmpC; OXA-1; SHV-12; TEM-1
    E. cloacae Romania cUTI >256 CTX-M-15; NDM-1; OXA-1; TEM-1
    E. cloacae/K. pneumoniae Russia cIAI 1/0.25 cAmpC/CTX-M-15; OXA-1; SHV-1; TEM-1
    E. coli Croatia cUTI 0.12 CTX-M-15
    E. coli Israel cUTI 0.5 CTX-M-15; OXA-1
    E. coli Romania cUTI 0.06 CTX-M-15; OXA-1
    E. coli Russia cUTI 0.25 CTX-M-15; OXA-1
    E. coli Romania cUTI 0.12 CTX-M-15; TEM-1
    E. coli Russia cIAI 0.12 CTX-M-15; TEM-1
    E. coli Russia cUTI ≤0.008 CTX-M-15; TEM-1
    E. coli Ukraine cUTI 0.06 CTX-M-15; TEM-1
    K. pneumoniae Bulgaria cUTI 1 CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Turkey cUTI 0.25 CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Turkey cUTI 0.5 CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Russia cUTI 0.5 CTX-M-15; OXA-1; SHV-11; TEM-1
    K. pneumoniae Russia cUTI 0.5 CTX-M-15; OXA-1; SHV-11; TEM-1
    K. pneumoniae Bulgaria cUTI 0.12 CTX-M-15; OXA-1; SHV-38; TEM-1
    K. pneumoniae Bulgaria cUTI 0.5 CTX-M-15; SHV-1
    K. pneumoniae Israel cUTI 4 KPC-3; SHV-11
    K. pneumoniae Bulgaria cUTI >256 NDM-1; SHV-11
    P. aeruginosa Russia cUTI 4 cAmpC
    P. aeruginosa Ukraine cUTI 64 OXA-10; VEB-1
    P. mirabilis Romania cUTI 0.5 ACC-4; TEM-1
    P. mirabilis Croatia cUTI 0.06 CMY-16
    P. mirabilis Bulgaria cUTI 0.5 CMY-16; SHV-12; TEM-1; VIM-1
BAT
    C. freundii France cUTI NA cAmpC; TEM-1
    C. freundii Bulgaria cUTI NA CTX-M-15; CTX-M-3; cAmpC; OXA-1
    E. cloacae Bulgaria cUTI NA CTX-M-15; CTX-M-3; cAmpC; OXA-1; TEM-1
    E. cloacae Israel cIAI NA CTX-M-15; OXA-1
    E. coli Israel cUTI NA CMY-2; TEM-1
    E. coli United States cUTI NA CMY-2; TEM-1
    E. coli Russia cUTI NA CMY-42; CTX-M-15; OXA-1
    E. coli Croatia cUTI NA CTX-M-15
    E. coli Peru cUTI NA CTX-M-15
    E. coli Bulgaria cIAI NA CTX-M-15; OXA-1
    E. coli Bulgaria cUTI NA CTX-M-15; OXA-1
    E. coli Israel cIAI NA CTX-M-15; OXA-1
    E. coli Israel cUTI NA CTX-M-15; OXA-1
    E. coli Mexico cUTI NA CTX-M-15; OXA-1
    E. coli Romania cUTI NA CTX-M-15; OXA-1
    E. coli Russia cIAI NA CTX-M-15; OXA-1
    E. coli Turkey cUTI NA CTX-M-15; OXA-1
    E. coli Bulgaria cUTI NA CTX-M-15; OXA-1; TEM-1
    E. coli Romania cUTI NA CTX-M-15; OXA-1; TEM-1
    E. coli Bulgaria cUTI NA CTX-M-15; TEM-1
    E. coli Bulgaria cUTI NA CTX-M-15; TEM-1
    E. coli Turkey cUTI NA CTX-M-15; TEM-1
    E. coli Turkey cUTI NA CTX-M-15; TEM-1
    E. coli Argentina cUTI NA CTX-M-2
    E. coli/E. coli Turkey cUTI NA CTX-M-15; CTX-M-3; TEM-1/CTX-M-15; TEM-1
    K. oxytoca Romania cUTI NA CTX-M-15; OXA-1; TEM-1
    K. oxytoca Bulgaria cUTI NA CTX-M-15; OXA-9; TEM-15
    K. pneumoniae Bulgaria cUTI NA CMY-4; CTX-M-15; OXA-1; SHV-1
    K. pneumoniae Ukraine cUTI NA CMY-4; CTX-M-15; SHV-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; CTX-M-3; SHV-1; TEM-1
    K. pneumoniae Romania cUTI NA CTX-M-15; OXA-1; SHV-1
    K. pneumoniae Russia cUTI NA CTX-M-15; OXA-1; SHV-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; OXA-1; SHV-1; SHV-11; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Peru cUTI NA CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Romania cUTI NA CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae United States cUTI NA CTX-M-15; OXA-1; SHV-1; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; OXA-1; SHV-11
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; OXA-1; SHV-11; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; OXA-1; SHV-11; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; SHV-1
    K. pneumoniae Romania cUTI NA CTX-M-15; SHV-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; SHV-1; TEM-1
    K. pneumoniae Romania cUTI NA CTX-M-15; SHV-11; SHV-12; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-15; SHV-38; TEM-1
    K. pneumoniae Bulgaria cUTI NA CTX-M-3; SHV-11
    K. pneumoniae Argentina cUTI NA KPC-2; SHV-11; TEM-1
    K. pneumoniae Russia cIAI NA OXA-2; SHV-18
    K. pneumoniae Bulgaria cUTI NA SHV-11; TEM-1; VIM-4
    P. aeruginosa Turkey cUTI NA cAmpC
    P. aeruginosa Turkey cUTI NA OXA-2; PER-1
    P. mirabilis Argentina cUTI NA CTX-M-3; OXA-9; SHV-5; TEM-1
    P. rettgeri Russia cUTI NA CTX-M-3; NDM-1; TEM-1
    S. marcescens Bulgaria cUTI NA CTX-M-15; CTX-M-3; OXA-1; TEM-1
a

TOC, test of cure; CAZ-AVI, ceftazidime-avibactam; BAT, best available therapy; cUTI, complicated urinary tract infection; cIAI, complicated intra-abdominal infection; NA, not available. cAmpC represents overexpression of the intrinsic chromosomal ampC gene according to qRT-PCR experiments.