TABLE 1.
MICs of β-lactams for P. aeruginosa NCGM3661 and NCGM3750 and E. coli transformants expressing VIM-2 and VIM-60
| Antibiotic | MIC (μg/ml) for: |
||||
|---|---|---|---|---|---|
|
P. aeruginosa |
E. coli transformant |
||||
| NCGM 3661 |
NCGM 3750 |
pHSG398/ VIM-2 |
pHSG398/ VIM-60 |
pHSG398 | |
| Ampicillin | >1,024 | >1,024 | 32 | 64 | 2 |
| Ampicillin- sulbactam |
>1,024 | >1,024 | 16 | 32 | 2 |
| Penicillin G | >1,024 | >1,024 | 64 | 128 | 32 |
| Aztreonam | 16 | 16 | 0.125 | 0.06 | 0.06 |
| Cefepime | 1,024 | 1,024 | 0.125 | 0.5 | 0.06 |
| Cefmetazole | >1,024 | >1,024 | 1 | 1 | 1 |
| Cefotaxime | >1,024 | >1,024 | 1 | 4 | ≤0.03 |
| Cefoxitin | 1,024 | 1,024 | 16 | 16 | 8 |
| Cefozopran | >1,024 | >1,024 | 0.5 | 4 | 0.06 |
| Cefpirome | >1,024 | 1,024 | 0.125 | 1 | 0.06 |
| Cefsulodin | >1,024 | >1,024 | 512 | 1024 | 256 |
| Ceftazidime | 256 | 128 | 1 | 4 | 0.125 |
| Ceftriaxone | 512 | 512 | 1 | 4 | ≤0.03 |
| Cefuroxime | >1,024 | >1,024 | 32 | 64 | 4 |
| Cephradine | >1,024 | >1,024 | 32 | 64 | 8 |
| Doripenem | 512 | 512 | ≤0.03 | 0.06 | ≤0.03 |
| Imipenem | 512 | 512 | 0.25 | 0.25 | 0.125 |
| Meropenem | 1,024 | 1,024 | ≤0.03 | 0.125 | ≤0.03 |
| Panipenem | 256 | 512 | 0.125 | 0.25 | 0.06 |
| Moxalactam | >1,024 | >1,024 | 8 | 16 | 0.125 |