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In vitro interaction of allopurinol with nitroheterocyclic compounds. (A) Fifty percent fractional inhibitory concentration (FIC50) of each drug in combination and ∑FIC50 of allopurinol plus benznidazole and allopurinol plus nifurtimox. (B) Graphical representations of the interaction between allopurinol and benznidazole. (C) Graphical representations of the interaction between allopurinol and nifurtimox.
