FIG 2.

QUADAS-2 assessments of the included studies. Patient Selection, describe the methods of patient selection; Index Text, describe the index test and how it was conducted and interpreted; Reference Standard, describe the reference standard (gold standard test) and how it was conducted and interpreted; Flow and Timing, describe any patients who did not receive the index tests or reference standard or who were excluded from the 2-by-2 table and describe the interval and any interventions between the index tests and the reference standard (26).