. Author manuscript; available in PMC: 2019 May 27.

Published in final edited form as: Mol Imaging Biol. 2018 Apr;20(2):221–229. doi: 10.1007/s11307-017-1109-3

Table 1.

Type and use of ultrasound contrast agents

	SLN identification	SLN characterization
	Sonazoid	Dual-targeted	Control
Manufacturer	GE Healthcare, Oslo, Norway	Targeson, San Diego, CA, USA	Targeson, San Diego, CA, USA
Diameter	1–6 μm	2–8 μm	2–8 μm
Composition	Lipid stabilized suspension of perfluorobutane	Streptavidin coated bubble filled with perfluorocarbon (labeled with P-selectin and α_vβ₃-integrin antibodies)	Streptavidin coated bubble filled with perfluorocarbon (labeled with immunoglobulin G)
Administration	Peritumoral injection	IV	IV
Dose	0.25 ml × 4	1.25 ml	1.25 ml