Table 3.
Pharmacokinetic parameters of total and unbound paclitaxel for nab-paclitaxel (260 mg/m2) in 24 patients treated with a 30 min infusion
| Parameters | Unbound Paclitaxel | Total Paclitaxel | ||
|---|---|---|---|---|
| Mean±SD (%CV) | Mean±SD (%CV) | |||
| Test | Reference | Test | Reference | |
| Tmax (h) | 0.5 (0.25, 0.51) | 0.5(0.25, 0.52) | 0.5(0.25, 0.52) | 0.5(0.25, 0.52) |
| Cmax (ng/mL) | 444.5±117.2 (26.37) | 476.7±125.2 (26.26) | 12,295±2370 (19.28) | 12,771±2065 (16.17) |
| AUC0–t (h*ng/mL) | 402.4±117.1 (29.11) | 440.1±143.1 (32.51) | 12,197±2841 (23.30) | 12,619±2754 (21.83) |
| AUC0–∞ (h*ng/mL) | 418.4±123.9 (29.62) | 456.4±145.3 (31.84) | 12,587±2932 (23.29) | 13,078±2880 (22.02) |
| t1/2 (h) | 21.61±9.43 (43.63) | 26.74±12.59 (47.09) | 24.48±4.47 (18.27) | 27.32±10.10 (36.96) |
Notes: Tmax, the values are expressed in terms of median (range).
Abbreviations: SD, standard deviation; CV, coefficient of variation; Tmax, time to peak concentration; Cmax, peak plasma concentration; AUC0–t, area under the curve to the last measurable concentration; AUC0–∞, area under the curve extrapolated to infinity; t1/2, elimination half-life.