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. 2019 May 21;12:4001–4011. doi: 10.2147/OTT.S195826

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© 2019 He et al.

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Proposed model of HEATR1-induced NSCLC cell apoptosis. HEATR1 inhibition could activate p53 signaling pathway via ribosome biogenesis stress, which subsequently leads to cell apoptosis and reduces cell survival through the activation of p53-PUMA-BAX/BCL2 axis.