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. 2019 May 20;10:543. doi: 10.3389/fphar.2019.00543

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Copyright © 2019 Song, Rahman, Jha, Gupta, Park, Kim, Lee, Lee, Sim, Bae, Lee and Suk.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of GNF-2 on STZ-induced diabetic pain. To investigate the role of c-Abl in STZ-induced pain phenotypes, GNF-2 was administered intraperitoneally at the indicated time point. STZ injection reduced PWL to heat (A) as well as PWT to force (B) when compared with vehicle-injected control animals. The STZ-induced pain hypersensitivity was attenuated in the GNF-2-injected mice (10 mg/kg). No significant change in pain-related behavior was observed in the contralateral sides and vehicle injected animals. ^∗p < 0.05 vs. vehicle + STZ-injected animals Student’s t test; n = 3 for each group; data are represented as mean ± SEM. d, day (s).