Table 4.

Study schedule.

study schedule	screening visit	study day	post- operative days 1–7
written informed consent	x
Demographics	x
medical history, concomitant diseases	x
inclusion/exclusion criteria	x
adverse event monitoring		x	X
evaluations/measurements according to table below		x
insertion of two microdialysis probes and equilibration		x
in-vivo calibration of microdialysis probes		x
administration of study drug		x
plasma for pharmacokinetics		x
microdialysate for pharmacokinetics		x
removal of microdialysis probes		x
monitoring incidence of surgical site infection within 1st week			X