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. 2019 May 10;11:1758835919833867. doi: 10.1177/1758835919833867

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — The membrane transporters on which palbociclib (OCT1, P-gp, BCRP) and ribociclib (P-gp, BCRP, OATP1B1, OATP1B3, OCT1, OCT2, BSEP, MATE1) can act are illustrated. According to an in vitro study, palbociclib and ribociclib act as inhibitors of these transporters. As a result, a greater amount of drugs that are substrates for these transporters would accumulate in the blood causing the appearance of adverse effects. Those coloured in green refer to the ABC superfamily efflux pumps. Those coloured in blue refer to the SLC superfamily, which uptake the drug in the enterocyte, hepatocyte, proximal tubule cell and neuron.ABC, ATP-binding cassette; BBB, blood brain barrier; BCRP, breast cancer resistance protein; BSEP, bile salt export pump; MATE1, multidrug and toxin extrusion protein; OATP, organic anion-transporting polypeptide; OCT, organic cationic transporter; P-gp, P-glycoprotein; SLC, solute carrier.