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. 2019 May 14;11:1758835919846806. doi: 10.1177/1758835919846806

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 8. — ICAM-1 neutralizing antibody protects against bone loss in intratibial 4T1-injected osteolytic mice.

4T1-Luc cells were injected into the bone marrow cavity of tibia, and intratibial injection of saline, soluble ICAM, IgG, or ICAM-neutralizing antibody were started from 7 days later, twice a week. (a) Evaluation of tumor growth was performed on day 21 by measuring luciferase activity; after sacrificing, tibias were analyzed by micro-CT scans (b), and bone volume (c), trabecular thickness (d), and trabecular pattern factor (e) were evaluated. Blood sera were also collected for evaluating TRAP activity (f). Representative pictures are shown for each group. Scale bar = 0.5 mm. Graphs show mean ± SD of at least three independent experiments.

^*p < 0.05; ^**p < 0.01 compared with tumor-bearing mice.

CT, computerized tomography; IgG, control immunoglobulin G antibody; ICAM-1, intercellular adhesion molecule-1; neu Ab, ICAM-1 neutralizing antibody; SD, standard deviation; sICAM, recombinant soluble ICAM.