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. 2019 May 14;13:1753944719841795. doi: 10.1177/1753944719841795

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© The Author(s), 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Cumulative data of progression of left-ventricular heart failure and hypertrophy after transverse aortic constriction.

Heart failure (a) and hypertrophy [heart weight, (b)] after transverse aortic constriction. While the LV heart weight increases significantly already after week 2, the LV function is preserved until week 3 (compensated hypertrophy) and deteriorates afterwards. The increase of heart weight in the control group is caused by the physiologic growth of the animals.

^*p < 0.05 versus 1 week.

^***p < 0.005 versus 1 week.

^#p < 0.001.

LV, left ventricular; LVEF, left-ventricular ejection fraction; TAC, transverse aortic constriction.