(A) The ROC curve analysis for the diagnostic value of MPV (AUC = 0.652, 95% CI = 0.587-0.717, P < .0001), RDW (AUC = 0.772, 95% CI = 0.718-0.826, P < .0001), MPV/PC ratio (AUC = 0.779, 95% CI = 0.724-0.834, P < .0001), NLR (AUC = 0.800, 95% CI = 0.749-0.852, P < .0001), PLR (AUC = 0.653, 95% CI = 0.589-0.717, P < .0001), and model (AUC = 0.922, 95% CI = 0.892-0.957, P < .0001) in 171 AFP-negative patients with HCC. (B) MPV–PC ratios of AFP-negative patients with HCC at different clinical stages (P = .034). (C) NLR of AFP-negative patients with HCC at different clinical stages (P = .024). (D) MPV of AFP-negative patients with HCC with different Child-Pugh scores (P = .013). (E) RDW values of AFP-negative patients with HCC with different Child-Pugh scores (P = .005). (F) MPV–PC ratios of AFP-negative patients with HCC at different Child-Pugh scores (P = .003). * P < 0.05, ** P < 0.01. AUC indicates area under the curve; HCC, hepatocellular carcinoma; MPV, mean platelet volume; NLR, neutrophils/lymphocytes ratio; RDW, red blood cell distribution width; PLR, platelet count/lymphocytes ratio; AFP, α-fetoprotein; ROC, receiver–operating characteristic.