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An AMPK inhibitor blocked the protective effect of metformin on cardiac function. (A) M-mode echocardiograms of the left ventricles are shown. (B) EF and FS values are shown. (C) HE and Masson's trichrome staining are shown. Scale bar, 60 μm. (D and E) Western blot analysis of collagen I and collagen III expression in the different groups. *P<0.05 compared to the control group, #P<0.05 compared to the DM group, &P<0.05 compared to the DM+Met group. n=5.
