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Metformin inhibits the NLRP3 pathway via AMPK/mTOR-dependent effects in diabetic mice. The expression levels of p-AMPK and AMPK (A), LC3 (B), mTOR (C), NLRP3 (D), caspase-1 (E) and IL-1β (F) were detected by western blotting. (G & H) Immunohistochemistry analysis was performed to detect NLRP3, caspase-1 and IL-1β expression. Scale bar, 60 μm. *P<0.05 compared to the control group, #P<0.05 compared to the DM group, &P<0.05 compared to the DM+Met group. n=5.
