Table 5.

Summary of completed trials with PARPi, mono and combination therapy

Clinicaltrials.gov identifier	Phase	Treatment	Tumor type	Outcome measures
NCT02000622	III	Olaparib vs chemotherapy (capacitabine, eribulin or vinorelbine)	HER2- BC	Median PFS: 7.0 vs 4.2 months Response rate: 59.9% vs 28.8%
NCT00494234	II	Olaparib: 400mg bid vs 100 mg bid	Advanced BC with BRCA1 or BRCA2 mutations	ORR: 41% vs 22% Median PFS: 5.7 months vs 3.8 months
NCT01078662	II	Olaparib	Ovarian, breast, pancreatic and prostate cancers	ORR: 31.1%, 13% 21.7% and 50.0%
NCT01945775	III	Talazoparib vs Chemotherapy	Advanced or HER2- BC with BRCA1 or 2 mutations	PFS: 8.6 months vs 5.6 months ORR: 62.6% vs 27.2% Median DoR: 5.4 Vs 3.2 months
NCT01042379	II	Veliparib-carboplatin vs standard therapy alone	TNBC	Pathological complete response rate: 51% vs 26%
NCT01149083	I/II	Veliparib vs veliparib with carboplatin	Metastatic BC with BRCA1/2 mutations	PFS: 8.7 vs 18.8 months
NCT01506609	II	Veliparib to temozolomide or carboplatin/paclitaxel Vs carboplatin/paclitaxel with placebo	Metastatic BC with BRCA1/2 mutations	PFS: 14.1 vs 12.3 months OS: 28.3 Vs 25.9 months ORR: 77.8% vs 61.3%
NCT02484404	I/II	Durvalumab plus olaparib or cediranib	Women's cancer	Disease control rate: 83% vs 75%