Table 10.
Cell proliferation and apoptosis in colon
| Groups | PCNA-LI§ | AI (%)§ | R= PCNA-LI/AI |
|---|---|---|---|
| Normal control | 17.5 ± 0.6 | 0.15 ± 0.02 | 116.66 ± 0.5 |
| DMH+DSS | 38.1 ± 1.3 | 0.08 ± 0.02 | 476.25 ± 0.2 |
| Ru-B 50 mg/kg | 30.9 ± 0.8 | 0.09 ± 0.01 | 309.00 ± 0.7 |
| Ru-B 100 mg/kg | 25.6 ±0.9** | 0.12 ±0.02## | 213.33 ± 0.7$$ |
| Ru-B 200 mg/kg | 18.2± 0.8* | 0.15 ± 0.04# | 121.33 ± 0.3$ |
| Baicalein 100mg/kg | 27.1 ± 0.02 | 0.10 ± 0.05 | 271.00 ± 0.2 |
| Ruthenium 100mg/kg | 20.2 ±0.18** | 0.13 ± 0.02## | 155.38 ± 0.4$$ |
LI= Labelling index, PCNA-LI= percentage of PCNA labelled cells/total number of cells counted, AI= Apoptotic index. R = PCNA-LI/AI. AI was calculated as the percentage of TUNEL positive cells/total number of cells counted. Values represents mean ± S.E. § Total number of six slides were evaluated per rat. Each field consisted 700 cells. * Significant difference between PCNA-LI of Ru-B 200 mg/kg vs carcinogen control animals (p<0.01). ** Significant difference between PCNA-LI of Ru 100 mg/kg, Ru-B 100 mg/kg vs carcinogen control animals (p<0.05). # Significant difference between AI of Ru-B 200 mg/kg vs carcinogen control (p<0.01). ## Significant difference between AI of Ru 100 mg/kg, Ru-B 100 mg/kg vs carcinogen control animals (p<0.05). $ Significant difference between R of Ru-B 200 mg/kg vs carcinogen control animals (p<0.01). $$ Significant difference between R of Ru 100 mg/kg, Ru-B 100 mg/kg vs carcinogen control animals (p<0.05)