Table 9.
Effect of ruthenium (Ru), baicalein (B) and ruthenium baicalein complex (Ru-B) on the expression of Bax, Bcl2, WNT and β-catenin in colon tissues.
| Groups | Bax§ | Bcl2§ | WNT§ | β-catenin§ |
|---|---|---|---|---|
| Control | 8.4 ± 0.8 | 7.3 ± 0.2 | 9.2 ± 0.4 | 8.5 ± 0.7 |
| DMH+DSS | 4.2 ± 0.4 | 22.6 ± 1.3 | 25.3 ± 0.6 | 20.0 ± 0.4 |
| Ru-B 50 mg/kg | 5.8 ± 0.5** | 19.1 ± 0.9** | 22.5 ± 0.2 | 17.1 ± 0.6 |
| Ru-B 100 mg/kg | 7.7 ± 0.2* | 13.6 ± 0.2** | 11.3 ± 0.7** | 10.3 ± 0.1** |
| Ru-B 200 mg/kg | 10.3 ± 1.7* | 9.5 ± 0.6* | 8.5 ± 0.1* | 8.8 ± 0.7* |
| Baicalein 100mg/kg | 6.5 ± 0.8 | 12.4 ± 0.9** | 13.0 ± 0.6** | 12.7 ± 0.4** |
| Ruthenium 100mg/kg | 5.8 ± 0.7** | 10.8 ± 0.8* | 9.5 ± 0.2* | 10.5 ± 0.6* |
§Each score represents the results of 6 slides per rat and 6 rats per group, mean ± S.E. (n=6). Each field were selected randomly for evaluation of percentage of immune-positive cells. * Significant difference between treated and carcinogen control (p<0.01). ** Significance difference between treated and carcinogen control (p<0.05).