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. 2019 Apr 21;15(5):1042–1051. doi: 10.7150/ijbs.31099

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Downregulation of Bim mitigated hypoxia-induced apoptosis and activated autophagy in hiPSC-CMs. (A) Measurement of hiPSC-CM viability using Caspase-3 activity assay after the indicated treatments. (B) Assessment of Ca2+ handling properties in hiPSC-CMs. (C) Representative flow cytometry analysis of hiPSC-CMs after Bim knockdown. (D) Level of Bim protein, Caspase-3 protein and autophagy-related proteins in hiPSC-CMs after Bim knockdown. H: hypoxia; shNC: Bim knockdown-negative control; shBim: Bim knockdown. (n=3; **P<0.01).