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. 2019 Apr 21;15(5):1042–1051. doi: 10.7150/ijbs.31099

Figure 6.

Figure 6

Schematic shows proposed mechanism for miR-30e-5p mediating hypoxia-induced apoptosis in hiPSC-CMs. miR-30e-5p, downregulated by hypoxia, inhibits hypoxia-induced hiPSC-CMs apoptosis by suppression of Bim protein, an apoptosis activator and autophagy repressor, thereby activating autophagy and apoptosis inhibition.