Tension-Dependent Phosphorylation Rate |
Increasing tension causes an exponential decrease in phosphorylation rate of Aurora B substrates at the outer kinetochore. |
(Kelly and Funabiki, 2009) |
Phosphorylation dependent Kinetochore Detachments |
Increasing the fraction of phospho-sites that are phosphorylated increases the probability of detachment. |
(Asbury et al., 2006; Cheeseman et al., 2006; Sarangapani et al., 2013) |
Tension Independent Dephosphorylation |
Phosphatases at the outer kinetochore de-phosphorylate Aurora B substrates. |
(Lampson and Cheeseman, 2011; Pinsky et al., 2009; Wurzenberger and Gerlich, 2011) |
Reattachment |
Detached kinetochores re-attach via microtubule search and capture. |
(Kalinina et al., 2013) |