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. Author manuscript; available in PMC: 2020 Apr 8.
Published in final edited form as: Dev Cell. 2019 Feb 21;49(1):63–76.e10. doi: 10.1016/j.devcel.2019.01.018
Behavior Model Assumption Reference or Explanation
Tension-Dependent Phosphorylation Rate Increasing tension causes an exponential decrease in phosphorylation rate of Aurora B substrates at the outer kinetochore. (Kelly and Funabiki, 2009)
Phosphorylation dependent Kinetochore Detachments Increasing the fraction of phospho-sites that are phosphorylated increases the probability of detachment. (Asbury et al., 2006; Cheeseman et al., 2006; Sarangapani et al., 2013)
Tension Independent Dephosphorylation Phosphatases at the outer kinetochore de-phosphorylate Aurora B substrates. (Lampson and Cheeseman, 2011; Pinsky et al., 2009; Wurzenberger and Gerlich, 2011)
Reattachment Detached kinetochores re-attach via microtubule search and capture. (Kalinina et al., 2013)