Table 3.
Correlation of SNP MMP-9 -1562 genotype with plasma levels of MMP-9 and biomarkers of organ dysfunction in sepsis and controls.
| Variables | Sepsis N = 270 | Infected but not septic N = 270 | ||||
|---|---|---|---|---|---|---|
| CC (n = 231) | CT + TT (n = 39) | P value | CC | CT + TT | P value | |
| MMP-9 (ng/mL) | 577 (218.1-1083) | 780 (397-1375) | .14 | 884 (535-1474) | 646 (172-1249) | .64 |
| TIMP-1 (ng/mL) | 305 (169-555) | 304 (186-640) | .63 | 222 (139-355) | 66 (34-162) | .05 |
| MAP (mmHg) | 68 (61-80) | 69 (67-72) | .39 | 70 (68-75) | 70 (68-73) | .72 |
| Platelets (mm3) | 230 (170-304) | 237 (168-300) | .93 | 245 (193-309) | 253 (204-299) | .59 |
| Creatinine (mg/dL) | 1.09 (0.74-1.95) | 0.98 (0.78-2.74) | .84 | 0.8 (0.6-0.9) | 0.6 (0.6-0.7) | .50 |
| BUN (mg/dL) | 25 (16.33-45.27) | 24 (16.3-36.9) | .40 | 14.5 (11.8-21.2) | 10.1 (9.4-11.7) | .1 |
| Bilirubin total (mg/dL) | 0.15 (0.07-0.23) | 0.12 (0.07-0.19) | .59 | 0.3 (0.2-0.5) | 0.2 (0.2-0.2) | .25 |
| NT-proBNP (pg/mL) | 2102 (613-8776) | 1656 (413-9554) | .79 | 323.6 (161.2-866.5) | 373 (138.2-876.2) | .83 |
| Troponin I (ng/mL) | 0.1 (0.1-0.19) | 0.1 (0.1-0.18) | .90 | 0.1 (0.1-0.1) | 0.1 (0.1-0.1) | .70 |
| SOFA | 2 (1-5) | 2 (1-4) | .36 | 1 (1-1) | 0 (0-0) | .1 |
| APACHE | 13.8 (8-19) | 12.65 (9-15) | .46 | 8 (6-10.5) | 4 (3.7-4) | .02 |
| CHARLSON | 2 (1-3) | 1 (1-4) | .78 | 1 (1-2) | 0 (0-0) | .03 |
Data presented as median (25th to 75th percentile).
Abbreviations: APACHE, Acute Physiology and Chronic Health Evaluation; BUN, blood urea nitrogen; CHARLSON, Charlson Comorbidity Index; MAP, mean arterial pressure; MMP-9, matrix metalloproteinase 9; proBNP, cerebral natriuretic peptide; SOFA, Sequential Organ Failure Assessment; TIMP-1, tissue inhibitor of metalloproteinase 1.