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. 2019 May 12;11:1759091419839515. doi: 10.1177/1759091419839515

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — FTD-associated regional alterations in neurotrophin and neurotrophin receptor immunoreactivity. Fresh-frozen postmortem microdissected control (n = 13) and FTD (n = 11) human brain samples from BA 8/9 (prefrontal), BA24 (anterior cingulate), and BA38 (temporal pole) were used to measure (a) BDNF, (b) NT3, (c) Trk, (d) NGF, and (e) NT4 by direct-binding ELISAs with results normalized to protein concentration. Levels of immunoreactivity were measured in arbitrary FLU. Box plots depict mean (horizontal bar), 95% confidence interval limits (upper and lower limits of the box), and range (stems). Data were analyzed by two-way ANOVA with the Tukey post hoc significance test. Significant between-group differences are indicated within the panels.

BA = Brodmann’s area; BDNF = brain-derived neurotrophic factor; FLU = fluorescence light unit; FTD = frontotemporal lobar degeneration; NGF = nerve growth factor; NT3 = neurotrophin-3; NT4 = neurotrophin-4; Trk = tropomyosin receptor kinase.