Skip to main content
. 2019 Apr 10;98(6):689–697. doi: 10.1177/0022034519839438

Figure 1.

Figure 1.

Biological and mechanical validation of a murine model of hyperloading. Dentition in (A) an intact state and (B) after mxM2 and mxM3 extraction, with the intention to hyperload mnM1. (C) An analogous condition in a patient who has lost mxM1 and mxM2. (D) Quantification of cusp height from (E–G) 3-dimensional (3D) micro–computed tomography (µCT) reconstructions of representative dentitions. Cusp height of mnM1 was measured from the tip of the buccal-middle cusp to the cementoenamel junction (arrows). (H) A 3D µCT reconstruction of mnM1 used in a 3D finite element model; arrow indicates alveolar bone surrounding mnM1, which was assigned appropriate material properties (see Methods). (I) Compressive stress distributions in the alveolar bone under normal occlusal load (top) and under hyperocclusal load (bottom). (J) Magnitude of the stress in alveolar bone of the furcation region. (K) A 3D µCT reconstruction of mnM1, where the PDL is assigned appropriate material properties (arrow). (L) Compressive strain distributions in the PDL under normal occlusal load (top) and under hyperocclusal load (bottom). (M) Calculated strains in the PDL occupying the furcation region. Scale bars = 200 µm. Values are presented as mean ± SD. *P < 0.05. mnM, mandibular molar; ns, not significant; PED, postextraction day; PDL, periodontal ligament.