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. 2019 Apr 8;98(6):713–719. doi: 10.1177/0022034519837240

Figure 2.

Figure 2.

Targeted overexpression of TNF-α in the salivary glands through AQP5-Cre-expressing mice. (A) A schematic demonstrating targeted conditional overexpression of TNF-α in the salivary glands that is generated by breeding AQP5-Cre mice with the TNF-αglo transgenic line. (B) The resulting AQP5/TNF-αglo mice display targeted overexpression of TNF-α (arrows) in the submandibular and lacrimal glands. (C) Elevated TNF-α mRNA levels demonstrated by quantitative real time PCR. (D) Elevated phosphorylation of NF-κB reveals active TNF-α signaling as a result of transgene recombination. *P < 0.05. Values are presented as mean ± SEM. AQP5, aquaporin 5; SMG, submandibular gland.