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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Environ Pollut. 2019 Feb 1;247:953–963. doi: 10.1016/j.envpol.2019.01.118

Figure 4. Chronic CAP exposure changes circulating circadian rhythm-related biomarkers.

Figure 4.

Mice were exposed to FA or CAP for 10 months. Their sera were collected and subjected to LC-MS and GC-MS analyses. Three circadian rhythm-related biomarkers, melatonin (A), 5-methoxytryptophol (B), retinal (C), were identified as differential metabolites. Other three melatonin metabolites, di-Hydroxymelatonin (D), melatonin glucuronide (E) and N-acetylserotonin (F) were also detected but not identified as differential metabolites. *p< 0.05 and VIP >1.0, multivariate statistical method and student t test.