KEY RESOURCES TABLE

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and Virus Strains
B.fragilis	ATCC	Cat# 25285
B.ovatus	ATCC	Cat# 8483
B. thetaiotaomicron	ATCC	Cat# 29741
B.uniformis	ATCC	Cat# 8492
M.morganii	ATCC	Cat# 25830
M.morganii	ATCC	Cat# 49948
Human Gut Microbiota Culture Collections from IBD Patients	Isolated from patients (Palm et al., 2014)	N/A
Chemicals, Peptides, and Recombinant Proteins
Gifu Anaerobic Broth	VWR	Cat# 11007–214
Desloratadine	Tocris	Cat# 5958
Tiotidine	Tocris	Cat# 0826
Iodophenpropit	Tocris	Cat# 0779
A987306	Tocris	Cat# 3640
Phenethylamine	Sigma-Aldrich	Cat# 241008
Tyramine	Sigma-Aldrich	Cat# T90344
Dopamine	Sigma-Aldrich	Cat# H8502
Histamine	Sigma-Aldrich	Cat# H7129
Acetylcholine	Sigma-Aldrich	Cat# A2661
L-DOPA	Sigma-Aldrich	Cat# D9628
Succinate	Sigma-Aldrich	Cat# 398055
Serotonin	Sigma-Aldrich	Cat# 14927
Gastrin	Sigma-Aldrich	Cat# G9145
Peptide YY	Anaspec	Cat# AS024401
Pancreatic polypeptide	Anaspec	Cat# AS-22866
Cholecystokinin	Sigma-Aldrich	Cat# C2175
Trace mineral supplement	ATCC	Cat# MD-TMS
Vitamin supplement	ATCC	Cat# MD-VS
L-glycine	Sigma-Aldrich	Cat# G8898
L-valine	Sigma-Aldrich	Cat# 94619
L-leucine	Sigma-Aldrich	Cat# L8000
L-isoleucine	Sigma-Aldrich	Cat# 12752
L-methionine	Sigma-Aldrich	Cat# 64319
L-histidine	Sigma-Aldrich	Cat# H8000
L-arginine	Sigma-Aldrich	Cat# A5131
L-phenylalanine	Sigma-Aldrich	Cat# P2126
L-tyrosine	Sigma-Aldrich	Cat# T3754
L-tryptophan	Sigma-Aldrich	Cat# T0254
N-methylphenethylamine	Sigma-Aldrich	Cat# M68423
Octopamine	Sigma-Aldrich	Cat# O0250
Synephrine	Sigma-Aldrich	Cat# S0752
Epinephrine	Sigma-Aldrich	Cat# E4250
Norepinephrine	Sigma-Aldrich	Cat# A7257
3-Methoxytyramine	Sigma-Aldrich	Cat# M4251
DMEM	Sigma-Aldrich	Cat# D6429
RPMI 1640	Thermo Fisher	Cat# 21870092
D-phenylalanine	Sigma-Aldrich	Cat# 673-06-3
FDAA (Marfey’s Reagent)	Thermo Fisher	Cat# 48895
Critical Commercial Assays
Bright-Glo™Luciferase Assay System	Promega	Cat# E2620
Histamine Elisa Kit	Enzo Life Sciences	Cat# ENZ-KIT140-0001
Deposited Data
Shotgun whole-genome sequencing data	This paper	PRJNA512876
iHMP metabolome data	NIH Integrative Human Microbiome Project (Integrative, 2014)	https://ibdmdb.org/tunnel/public/HMP2/Metabolites/1723/products
iHMP metagenome data	NIH Integrative Human Microbiome Project (Integrative, 2014)	https://ibdmdb.org/tunnel/public/HMP2/Metabolites/1723/products
M. morganii whole genomes (previously deposited)	NCBI	https://www.ncbi.nlm.nih.gov/genome
Experimental Models: Cell Lines
HTLA cells	(Barnea et al., 2008)	N/A
HEK293T	ATCC	Cat# CRL-3216
Experimental Models: Organisms/Strains
Germ-free C57Bl/6 mice	University of Michigan Gnotobiotics Center	https://microbe.med.umich.edu/services/germ-free-gnotobiotic-mouse-facilities
Recombinant DNA
PRESTO-Tango Plasmids	Addgene; (Kroeze et al., 2015)	Kit #1000000068
Gαs-Gαt and Gαs-Gαo chimeras	(Liberles and Buck, 2006)	N/A
CRE-SEAP reporter plasmid	(Liberles and Buck, 2006)	N/A
Software and Algorithms
QIIME2 2018.8	QIIME 2 development team, 2018	https://qiime2.org/
DADA2 (QIIME2 plugin)	(Callahan et al., 2016)	http://benjjneb.github.io/dada2/
Trimmomatic v.0.38	(Bolger et al., 2014)	http://www.usadellab.org/cms/?page=trimmomatic
SPAdes 3.13.0	(Bankevich et al., 2012; Nurk et al., 2013)	http://cab.spbu.ru/files/release3.13.0/manual.html
RAST server	(Aziz et al., 2008)	http://rast.nmpdr.org/rast.cgi?page=Jobs
BBMap	DOE Joint Genome Institute	https://sourceforge.net/projects/bbmap/
Other
600 MHz NMR system with a cryoprobe	Agilent	N/A
iFunnel 6550 ESI-HRMS-QTOF	Agilent	N/A
1260 Infinity system	Agilent	N/A
Prepstar HPLC	Agilent	N/A
Anaerobic Chambers	Coy	Custom built
Spectramax i3x plate reader	Molecular Devices	I3X
Gnotobiotic isolators	Class Biologically Clean	N/A
Isocage P Microisolator Caging System	Techniplast	ISO72P