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. Author manuscript; available in PMC: 2019 May 27.
Published in final edited form as: J Hepatol. 2017 Feb 3;66(5):1037–1046. doi: 10.1016/j.jhep.2017.01.022

Fig. 2. Effects of conditions causing NASH on hepatic expression of NLRP3, pro-caspase 1, active caspase 1, pro-IL-1β and IL-1β.

Fig. 2.

(A) NLRP3 in wild-type (Wt) and foz/foz mice after 24 weeks atherogenic diet, and gavage during the last 8 weeks with vehicle (saline) or MCC950. (B) Hepatic pro-caspase 1 (p45), (C) active caspase 1 (p10), (D) pro-IL-1β (p30), and (E) IL-1β (p17). (F) Representative Western blot analyses from same experiments, with heat shock protein 90 (HSP90) as loading controls. *p <0.05 vs. Wt. #p <0.05 MCC950 vs. vehicle, by one-way ANOVA, n = 6–10 animals/group.