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. Author manuscript; available in PMC: 2019 May 27.
Published in final edited form as: J Hepatol. 2017 Feb 3;66(5):1037–1046. doi: 10.1016/j.jhep.2017.01.022

Fig. 6. MCC950 suppresses liver fibrosis in obese, diabetic mice with NASH.

Fig. 6.

(A) Sirius Red-stained liver sections from Wt and foz/foz mice after 24 weeks atherogenic diet intake and gavage during the last 8 weeks with vehicle or MCC950 (same mice as in Figs. 2–4). (B) Collagen area by Sirius Red densitometry. (C) Changes in collagen 1α (Col-1), (D) alpha-smooth muscle actin (α-SMA), (E) connective tissue growth factor (CTGF), and (F) representative Western blot analyses. Heat shock protein 90 (HSP90) as loading control. *p <0.05 or less vs. Wt. #p <0.05 MCC950 vs. vehicle, by one-way ANOVA, n = 6–10 animals/group. Scale bar: 100 μm.