Table 5:
Cox unadjusted and adjusted HRCT prognostic features in interstitial pneumonia with autoimmune features.
| Unadjusted (n=136) | Adjusted* (n=136) | ||||||
|---|---|---|---|---|---|---|---|
| Variable | HR | p-value | 95% CI | HR | p-value | 95% CI | |
| Honeycomb pattern | 2.60 | 0.005 | 1.33 – 5.07 | 2.17 | 0.037 | 1.05 – 4.47 | |
| Reticulation (% involvement) | 1.04 | 0.001 | 1.01 – 1.06 | 1.01 | 0.386 | 0.98 – 1.05 | |
| Multicompartment features | |||||||
| Mosaic attenuation excluding emphysema^ | 2.17 | 0.011 | 1.19 – 3.95 | 1.79 | 0.117 | 0.87 – 3.70 | |
| Pulmonary artery enlargement | 2.23 | 0.009 | 1.22 – 4.05 | 2.08 | 0.043 | 1.02 – 4.20 | |
| UIP Pattern** | |||||||
| Possible UIP | 0.99 | 0.982 | 0.36 – 2.73 | ||||
| Definite UIP | 1.57 | 0.172 | 0.82 – 2.98 | ||||
| Mosaic attenuation | 1.63 | 0.102 | 0.91 – 2.94 | ||||
| Ground-glass opacities | 0.99 | 0.968 | 0.52 – 1.88 | ||||
| Axial distribution of fibrosis*** | |||||||
| Peripheral | 1.40 | 0.575 | 0.43 – 4.56 | ||||
| Peripheral with subpleural sparing | 0.32 | 0.325 | 0.03 – 3.09 | ||||
| Diffuse | 1.29 | 0.722 | 0.32 – 5.17 | ||||
| Pleural or pericardial effusion or thickening | 1.77 | 0.146 | 0.82 – 3.81 | ||||
*
adjusted for age, gender, fvc, dlco and presence of clinical domain
**
compared to ‘Inconsistent with UIP’
***
compared to central/bronchovascular pattern
+
using a pulmonary artery diameter cutoff of 33mm
^
multicompartment features excluding patients with smoking history: univariate analysis HR=1.83; p=0.047