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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2019 May;39(5):902–914. doi: 10.1161/ATVBAHA.118.312301

Figure 6. KLF4 regulates ITPR3 by modulating chromatin accessibility.

Figure 6.

(A) Putative KLF4 binding sites, PS- or OS-induced H3K27ac enrichment, and Ad-null- or Ad-KLF4-induced ATAC signals in the ITPR3 promoter. (B, C) HUVECs were infected with Ad-null or Ad-KLF4 for 24 hr. KLF4 binding to the ITPR3 promoter and H3K27ac enrichment of the ITPR3 promoter were detected by KLF4 ChIP-qPCR and H3K27ac ChIP-qPCR, respectively. The used PCR primers were depicted by arrows in Panel A. Data are mean ± SEM from at least 3 independent experiments. Statistical significance was determined by 2-tailed Mann-Whitney U test between two indicated groups. *P < 0.05.