Table 2.
Multilevel models indicating associations between APOE ε4 carrier status, childhood socioeconomic status, and cognition (in percent of maximum possible) at age 65 baseline and change across a seven-year period (N = 3017).
| Memory | Language/Executive Function | |||
|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |
| B (SE) | B (SE) | B (SE) | B (SE) | |
| Fixed Components | ||||
| Change over 7 years | − 9.50*** (1.54) | − 9.56*** (1.54) | −6.51*** (0.93) | −6.47*** (0.93) |
| APOE ε4 carrier (baseline) | − 0.73 (0.57) | − 0.85 (0.57) | 0.11 (0.42) | 0.12 (0.42) |
| APOE ε4 carrier (change) | − 1.76** (0.69) | − 1.63* (0.69) | 0.04 (0.45) | −0.02 (0.45) |
| Childhood SES (baseline) | 0.46 (0.28) | − 0.03 (0.32) | 0.76*** (0.21) | 0.79** (0.24) |
| Childhood SES (change) | − 0.37 (0.34) | 0.12 (0.39) | 0.16 (0.22) | −0.05 (0.25) |
| Carrier* childhood SES (baseline) | – | 1.80** (0.57) | - | −0.13 (0.43) |
| Carrier* childhood SES (change) | – | − 1.91** (0.70) | - | 0.81 (0.45) |
| Random Components | ||||
| Person-level intercept | 7.67 (0.25) | 7.68 (0.25) | 7.17 (0.16) | 7.17 (0.16) |
| Observation-level intercept | 11.46 (0.16) | 11.44 (0.16) | 7.40 (0.10) | 7.40 (0.10) |
| Deviance; df | 45,953; 21 | 45,942; 23 | 42,172; 21 | 42,169; 23 |
Note. Childhood SES is standardized. All models include the effects on baseline and change of: the other domain of cognitive function; IQ; gender; geographic setting in adolescence; family structure; number of siblings; and hearing problems.
***
p < .001
**
p < .01
*
p < .05.