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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Bone Miner Res. 2019 Mar 28;34(5):797–809. doi: 10.1002/jbmr.3708

Table 2.

miRNA functional data during fracture repair. These studies either increased or decreased individual miRNAs levels.

Model Target miRNA Observed Results Study
Mouse femoral transverse fracture ↓miR-92a Increased callus volume and neovascularization (41)
Rat transverse femoral fracture ↑miR-21 Accelerated endochondral ossification; greater bone volume; increased ultimate load and energy to failure (42)
Mouse femoral transverse fracture ↑miR-29b-3p Decreased callus width and area; increased callus bone volume and density; increased stiffness (44)
Rat transverse femoral fracture and cauterization of the periosteum ↓miR-222 Bone union; Increased callus capillary density (45)
Mouse femoral transverse fracture ↑miR-142–5p Increased Runx2 and osteocalcin expression; increased callus bone mineral density (48)
Mouse femoral transverse fracture ↑miR-218 Increased Osterix and Osteocalcin expression; bone volume; increased ultimate load and energy to failure (49)
Rat transverse femoral fracture ↑miR-148a Decreased callus width and area; higher bone mineral density; increased biomechanical strength (maximum load, stiffness, and energy absorption) (50)
Mouse femoral transverse fracture ↑miR-185 In fracture bone-derived osteoblasts: decreased levels of PTH, β-catenin and Wnt5b; stimulated osteoblast viability; reduced apoptosis with more cells arrested at G1 (51)