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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: J Bone Miner Res. 2019 Mar 28;34(5):797–809. doi: 10.1002/jbmr.3708

Table 4.

Expression and function comparison between free and exosomal miRNAs.

miRNA Free Expression (Study) Exosomal Expression (Study)
miR-140–3p Serum from osteoporotic fracture patients – Upregulated (33)
Callus from rat nonunion fractures – Downregulated (35)
Callus from mouse transverse fractures – Upregulated (36)		 Osteoblast-derived – Promotes osteoblast differentiation (67)
miR-148a Serum from osteoporotic fracture patients – Upregulated (29) Osteoblast precursors – Promotes osteoclastogenesis (68)
Human BMSCs – Enhances osteoblast differentiation (69)
miR-218 Overexpressing BNSCs – Enhances mouse fracture healing (49) Osteoblast precursors – Promotes osteoclastogenesis (68)
Human BMSCs – Enhances osteoblast differentiation (69)
miR-214 Overexpressing BMSC – Enhances rat bone defect healing (54)
Femoral head trabecular bone from patients with osteoporotic hip fractures – Upregulated (31)		 Osteoclast-derived – Inhibits bone formation (70)
miR-29b-3p Plasmids expression – Enhances mouse fracture healing (44) MSC-derived – Enhances mouse fracture repair (66)