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. Author manuscript; available in PMC: 2020 Jul 15.
Published in final edited form as: Neuroimage. 2019 Apr 4;195:320–332. doi: 10.1016/j.neuroimage.2019.03.073

Table 3.

Linear mixed-modeling results

Predictor Model Fit Year Predictor Predictor × Year
FA in DMN-naWM AIC = 179.57 F1,78.9 = 9.97 (p = .002)
β = −2.75 [−4.50, −1.02] 		F1,47.8 = 2.77 (p = .103)
β = 6.75 [−1.41, 14.91]		 F1,78.9 = 9.27 (p = .003)
β = 4.58 [1.59, 7.57]
DMN deactivation AIC = 200.41 F1,78.4 = 7.64 (p = .007)
β = −0.16 [−0.28, −0.05] 		F1,43.5 = 0.73 (p = .396)
β = −0.16 [−1.32, 3.28]		 F1,77.9 = 2.13 (p = .149)
β = 0.54 [−0.20, 1.27]
FA in ECN-naWM AIC = 178.55 F1,78.9 = 13.83 (p < .001)
β = −3.03 [−4.66, −1.41] 		F1,81.2 = 0.26 (p = .871)
β = −0.76 [−10.13, 8.60]		 F1,79.0 = 12.96 (p = .001)
β = 5.16 [2.31, 8.01]
ECN Activation AIC = 203.89 F1,78.9 = 5.14 (p = .026)
β = −0.13 [−0.23, −.02]		 F1,76.0 = 3.78 (p = .056)
β = −1.35 [−2.74, 0.03]		 F1,79.1 = 0.54 (p = .464)
β = 0.15 [−0.25, 0.54]
WMH Volume AIC = 206.17 F1,78.2 = 0.78 (p = .781)
β = 0.16 [−0.99, 1.32]		 F1,79.1 = 2.55 (p = .114)
β = −0.34 [−0.77, 0.08]		 F1,78.1 = 0.20 (p = .655)
β = −0.03 [−0.15, 0.09]
CSF tau/Aβ42 AIC = 205.70 F1,78.3 = 3.99 (p = .049)
β = −0.29 [−0.57, −0.001]		 F1,41.6 =0.002 (p = .97)
β = 0.27 [−1.27, 1.30]		 F1,78.2 = 1.83 (p = .181)
β = −0.27 [−0.68, 0.13]

Results of separate linear mixed-models are shown in each row above. The model-fit is described by AIC, where lower values indicate a better fit. For each fixed-effect the fit statistic and un-standardized β co-efficient estimates are provided with the p-value and [95% CI], respectively. Significant effects with p < .008 are indicated in bold. All models included an intercept term.