Table 2. Rebiopsy Methods and Their Success Rate and Complications (n=112).
| Site | Method | Number of patients | Success, n (%) | T790M reported, No. of patients with successful tissue biopsy, n (%) | Complications |
|---|---|---|---|---|---|
| Intrathoracic site | |||||
| Lung parenchyme | Bronchoscopic endobronchial biopsy only | 12 | 10 (83.3) | 5 (50.0) | None |
| Bronchoscopic biopsy with TBLB | 24 | 18 (75.0) | 7 (38.9) | Bleeding (clinically significant), 1 | |
| CT-guided percutaneous lung biopsy | 18 | 14 (77.8) | 9 (64.3) | Pneumothorax, 1 | |
| US-guided lung biopsy | 5 | 4 (80.0) | 3 (75.0) | None | |
| Biopsy under VATS | 6 | 6 (100) | 6 (100) | None | |
| Mediastinal lymph node | EBUS-TBNA | 14 | 11 (78.6) | 6 (54.5) | None |
| Pleural effusion | Thoracentesis | 11 | 9 (81.8) | 4 (44.4) | None |
| Extrathoracic site | |||||
| Neck node | US-guided lymph node biopsy | 10 | 10 (100) | 6 (60.0) | None |
| Liver | US-guided liver biopsy | 7 | 6 (85.7) | 1 (16.7) | None |
| CSF | Spinal tapping | 7 | 4 (57.1) | 1 (25.0) | None |
| Ascites | Paracentesis | 3 | 3 (100) | 3 (100) | None |
| Bone | Bone biopsy via CT | 2 | 2 (100) | 0 (0.0) | None |
| Skin | Skin biopsy | 2 | 1 (50.0) | 1 (100) | None |
| Brain | Brain surgery | 2 | 2 (100) | 0 (0.0) | None |
TBLB, transbronchial lung biopsy; US, ultrasound; VATS, video-assisted thoracoscopic surgery; EBUS, endobronchial ultrasound; TBNA, transbronchial needle aspiration; CSF, cerebrospinal fluid.