Table 3. Subgroup Analysis of Non-ECRSwNP and ECRSwNP Groups.
Non-ECRSwNP (n=57) | p value | ECRSwNP (n=77) | p value | |||
---|---|---|---|---|---|---|
Disease-controlled (n=33) | Disease-uncontrolled (n=24) | Disease-controlled (n=46) | Disease-uncontrolled (n=31) | |||
Age (yr) | 54 (45–61) | 51 (31–59) | 0.301* | 56 (51–60) | 42 (3–54) | 0.002* |
Sex (male:female) | 25:8 | 17:7 | 0.911† | 38:8 | 21:10 | 0.093† |
Atopic | 18/33 (54.5) | 13/23(43.5) | 1.000† | 22/44 (50) | 14/30 (46.7) | 0.964† |
Asthma | 1/33 (3.0) | 2/24 (8.3) | 0.567‡ | 5/45 (11.1) | 8/31 (25.8) | 0.125† |
Symptom duration (month) | 13.4 (3.3–72.0) | 67.7 (24.0–120.0) | 0.021* | 42 (12–150) | 60 (18–120) | 0.989* |
Lund-Mackay score | 14 (11–18) | 18 (11–20) | 0.274* | 14 (10–17) | 20 (15–22) | <0.001* |
Global osteitis score | 9 (6–18) | 16 (2–23) | 0.096* | 11 (4–17) | 20 (10–26) | 0.008* |
BTT | 4 (0–8) | 3 (0-8) | 0.499* | 5 (0–8) | 0 (0–5) | 0.084* |
Tissue eosinophil (cells/HPF) | 3.3 (0.5–10.6) | 10.4 (1.3–29.9) | 0.166* | 17.3 (6.7–80.0) | 70.0 (15.9–105.0) | 0.054* |
Tissue neutrophil (cells/HPF) | 16.5 (9.0–26.8) | 46.0 (21.5–69.5) | 0.004* | 10.3 (3.0–17.7) | 15.0 (6.1–40.6) | 0.125* |
Blood eosinophil (cells/mm3) | 116 (79–150) | 115 (60–208) | 0.897* | 308 (239–417) | 437 (346–707) | 0.002* |
Blood neutrophil (cells/mm3) | 3623 (3205–4384) | 4027 (3022–5251) | 0.678* | 3702 (2607–4124) | 3892 (2779–4879) | 0.508* |
Current smoking | 10/33 (30.3) | 7/24 (29.2) | 1.000† | 13/46 (28.3) | 11/31 (35.5) | 0.674† |
Smoking history (pack-year) | 0 (0–18.4) | 0 (0–2.5) | 0.855* | 0 (0–6.0) | 0 (0–6.3) | 0.587* |
Alcohol intake (g/month) | 100 (0–672) | 28 (0–168) | 0.211* | 0 (0–224) | 0 (0–324.8) | 0.928* |
Heavy drinker | 8/33 (3.4) | 3/24 (20) | 0.326‡ | 4/45 (8.9) | 2/31 (6.5) | 1.000‡ |
BMI (kg/m2) | 24.6 (22.6–26.0) | 23.3 (21.4–26.2) | 0.268* | 24.6 (22.4–26.3) | 23.8 (21.9–24.9) | 0.262* |
ECRSwNP, eosinophilic chronic rhinosinusitis with nasal polyps; BTT, butanol threshold test; HPF, high power field; BMI, body mass index.
Values are presented as medians with IQRs or numbers (percentages).
*Mann-Whitney U-test, †Pearson chi-square test, ‡Fischer's exact test.