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. 2019 May 22;60(6):500–508. doi: 10.3349/ymj.2019.60.6.500

Fig. 2. IL-2 induced activation of NK cells and dysregulation of miR-218-5p and SHMT1 expression. NK-92 cells were treated by IL-2 (20 ng/mL) for 24 h. (A and B) TNF-α and IFN-γ production levels were determined by ELISA in NK-92 cells with or without IL-2 stimulation. (C) Effect of IL-2 on miR-218-5p expression was investigated in NK-92 cells. (D) SHMT1 protein expression was detected in NK-92 cells after or before IL-2 treatment. *p<0.05, IL-2-treated group vs. control group. IL-2, interleukin-2; NK, natural killer; SHMT1, serine hydroxymethyl transferase 1; TNF-α, tumor necrosis factor-α; IFN-γ, interferon-γ.

Fig. 2