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. 2019 May 28;5:29. doi: 10.1038/s41421-019-0101-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic view of AimR–DNA contacts. The bases are labeled according to the symmetry of the DNA sequence. Hydrophobic contacts are shown as green arrows, while nonspecific interactions are indicated by blue dotted lines. b Key residues and nucleotides involved in the interactions. Protein side chains and DNA bases are shown in a stick representation. DNA phosphate backbones and bases are colored orange and pink, respectively. c Examination of the DNA-binding affinity of AimR toward various DNA. The DNA sequence of each probe and the respective K_d values are listed in the table. The varied nucleotides are highlighted in red. Error bars indicate the s.d. of at least three independent measurements (the points are the mean)