Table 2.
Domain enrichment analysis of cytosolic proteins susceptible to glycation by methylglyoxal.
| Process | Protein domain | Count | Fold enrichment |
|---|---|---|---|
| Protein folding | Chaperonin TCP-1, conserved site | 7 | 68.1 |
| TCP-1-like chaperonin intermediate domain | 7 | 51.1 | |
| GroEL-like equatorial domain | 7 | 40.9 | |
| Chaperonin Cpn60/TCP-1 | 7 | 38.3 | |
| GroEL-like apical domain | 7 | 38.3 | |
| Signal transduction | 14-3-3 domain | 5 | 62.5 |
| Proteolysis | Proteasome, subunit alpha/beta | 8 | 36.9 |
| Protein synthesis | Aminoacyl-tRNA synthetase, class II | 6 | 30.9 |
| Actin cytoskeleton | Actin/actin-like conserved site | 7 | 29.2 |
| Actin, conserved site | 6 | 29.2 | |
| Actinin-type, actin-binding, conserved site | 6 | 22.8 | |
| Actin-related protein | 7 | 18.0 | |
| Protein synthesis | Aminoacyl-tRNA synthetase, class I, conserved site | 5 | 29.2 |
| Nucleotide binding | Rossmann-like alpha/beta/alpha sandwich fold | 7 | 14.6 |
Significant: P < 0.05 after Bonferroni correction and FDR < 0.05.