Table 2.

The cerebral adrenoleukodystrophy neurologic function score (NFS) used to evaluate gross clinical neurologic status for the cALD cohort pre-transplantation.

Neurologic Function Score	Points
Hearing/auditory processing problems	1
Aphasia/apraxia	1
Loss of communication	3
Vision impairment/fields cut	1
Cortical blindness	2
Swallowing difficulty or other central nervous system dysfunction	2
Tube feeding	2
Running difficulties/hyperreflexia	1
Walking difficulties/spasticity/spastic gait (no assistance)	1
Spastic gait (needs assistance)	2
Wheelchair required	2
No voluntary movement	3
Episodes of incontinency	1
Total incontinency	2
Nonfebrile seizures	1
	25 total

Note that a score of zero denotes absence of clinical signs of cerebral disease. Maximal signs within a domain score the total of all grades within that domain (for example, a patient with “total urinary or fecal incontinency” scores 3, for the sum of “Episodes of incontinency” [1 point] and “Total Incontinency” [2 additional points]).