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. 2019 May 27;9:7866. doi: 10.1038/s41598-019-44256-6

Table 1.

Antimicrobial scores of short peptides of HNP-1 obtained from AntiBP, AntiBP2, CAMP and AMPA servers.

Peptide fragments Position Antimicrobial Score Charge *Antimicrobial motif
AntiBP AntiBP2 CAMP AMPA
ACYCRIPACIAGERR 1–15 1.001 0.454 0.662 +2 Yes
CYCRIPACIAGERRY 2–16 1.120 0.702 0.816 +2 Yes
YCRIPACIAGERRYG 3–17 0.276 0.566 0.656 +2 NO
CRIPACIAGERRYGT 4–18 1.080 1.048 0.377 +2 NO
RIPACIAGERRYGTC 5–19 0.833 0.249 0.682 +2 Yes
IPACIAGERRYGTCI 6–20 1.425 0.629 0.296 +1 NO
PACIAGERRYGTCIY 7–21 0.261 0.996 0.505 +1 NO
ACIAGERRYGTCIYQ 8–22 0.829 0.637 0.519 +1 Yes
CIAGERRYGTCIYQG 9–23 0.515 0.051 0.450 +1 Yes
IAGERRYGTCIYQGR 10–24 0.368 0.242 0.357 +2 NO
AGERRYGTCIYQGRL 11–25 0.652 0.151 0.662 +2 Yes
GERRYGTCIYQGRLW 12–26 0.643 1.066 0.885 +2 NO
ERRYGTCIYQGRLWA 13–27 −0.593 0.513 0.955 +2 NO
RRYGTCIYQGRLWAF* 14–28 0.806 0.089 0.946 0.218 +3 Yes
RYGTCIYQGRLWAFC 15–29 0.302 0.467 0.840 +2 NO
YGTCIYQGRLWAFCC 16–30 0.447 0.287 0.325 +1 NO

The peptide highlighted in bold has antimicrobial potential based on antimicrobial score predictions by respective servers. *Antimicrobial motif: a short peptide having highest positive charge and predicted as antimicrobial based on scores obtained from all the servers. The motif RRYGTCIYQGRLWAF (highlighted in box) was selected as motif based on its antimicrobial score predictions.