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. 2019 May 27;9:7867. doi: 10.1038/s41598-019-44331-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TAC cardiomyocytes present a higher frequency and abundance of SERCA2A-containing nuclear invaginations. (a) Cardiomyocyte nuclei imaged with dSTORM were analyzed for presence of invaginations containing target SR proteins and number of cells with nuclear invaginations for each condition were plotted. n = 3. (b) Representative nuclei of dSTORM-imaged SERCA2A-containing nuclear invaginations in sham, 2-week TAC, and 4-week TAC cardiomyocytes.