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. 2019 May 27;9:7867. doi: 10.1038/s41598-019-44331-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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dSTORM imaging reveals cellular stress induces nanoscale changes in SR protein cluster properties. (a–d) Adult mouse ventricular cardiomyocytes were isolated, treated with control and 5 μg/mL tunicamycin conditions, and immunofluorescence was conducted to visualize (a) RyR2 and (b) SERCA2A by dSTORM imaging. (c,d) Voronoi tessellation was performed to quantify and plot changes in protein cluster properties, number of detection, cluster area, and cluster density (right). (a,b) Top panels scale bar = 3 μm, bottom panels scale bar = 2 μm. N = 10 cells per protein per condition.