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. 2019 May 21;10:1111. doi: 10.3389/fimmu.2019.01111

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Copyright © 2019 Ruiz-Limon, Ortega-Castro, Barbarroja, Perez-Sanchez, Jamin, Patirives, Luque-Tevar, Ibáñez-Costa, Perez-Sanchez, de la Rosa, Abalos-Aguilera, Jimenez-Gomez, Calvo-Gutierrez, Font, Escudero-Contreras, Alarcon-Riquelme, Collantes-Estevez and López-Pedrera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD16⁺ monocytes exhibit a prevalence of target mRNAs involved in atherosclerosis. (A) Number of altered microRNAs in CD14⁺ and CD16⁺ RA monocytes compared to HDs. 31 were specifically regulated in CD14⁺ RA monocytes, 153 were specifically regulated in CD16⁺ RA monocytes and 20 microRNAs were commonly altered in both subtypes in RA patients compared to HDs. (B) Among all the altered microRNAs in CD14⁺ and CD16⁺ RA monocytes, number of microRNAs involved in atherosclerosis pathway according to IPA. (C) Putative mRNA targets of the microRNAs altered in CD14⁺ RA monocytes compared to CD14⁺ HD monocytes involved in atherosclerosis according to IPA. (D) Putative mRNA targets of the microRNAs altered in CD16⁺ RA monocytes compared to CD16⁺ HD monocytes involved in atherosclerosis according to IPA.