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. 2019 May 21;10:542. doi: 10.3389/fphar.2019.00542

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Copyright © 2019 Dawood, Ooko and Efferth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Western blot analysis of NF-κB, IκB, and HIF-1α in parthenolide-treated multidrug-resistant MDA-MB-231-BCRP and sensitive MDA-MB-231-pcDNA3 cell lines (A) represents protein analysis for MDA-MB-231-BCRP while (B) represents protein analysis for MDA-MB-231-pcDNA. Cells were incubated with 5, 10, and 25 μM parthenolide and DMSO as negative control for 6 h. Then, total protein was extracted and Western blotting was performed. The chart shows the change in the protein expression after normalization to β-actin as mean ± SD for two independent experiments. Asterisk (^∗) indicates statistical significant inhibition (p < 0.05) while two asterisks (^∗∗) indicate statistical significant (p < 0.01) compared to DMSO-treated control cells.