Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 21;10:1079. doi: 10.3389/fimmu.2019.01079

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Shinde, Melinkeri, Santra, Kale and Limaye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

MM-Mo-DCs and MM-SC-DCs generated from the same MM samples showed differences at the molecular level. (A) MM-Mo-DCs showed significantly reduced migration toward CCL-19, as opposed to MM-SC-DCs. When MM-Mo-DCs were differentiated in presence of anti-IL6 antibody, their migration capacity was restored. (B) Expression of the IL-6 mRNA in precursors of MM-SC-DCs was significantly lower, as compared to that of MM-Mo-DC precursors. Expression of CCR7 at (C) the transcript and (D) the protein level was significantly lower in MM-Mo-DCs in comparison with MM-SC-DCs as analyzed by Real time PCR and FACS, respectively. (E) Relative enrichment of H3K4me³ at the Ccr7 promoter in MM-SC-DCs was significantly higher, as compared to MM-Mo-DCs. (F) Levels of the mRNA of transcription factor Zbtb46 were significantly higher in MM-SC-DCs, as opposed to those in MM-Mo-DCs. Data given are mean ± S.E.M p ≤ 0.001 (***).