Figure 5.

Akt agonist or inhibitor reversed the modulation effects of CLEC5A on glioblastoma cell lines, respectively. A, Anti‐proliferation effect of CLEC5A shRNA on U251 cell was reversed by Akt agonist IGF‐1. Cell growth was detected with CCK‐8. B, CLEC5A overexpression increased U87 cell proliferation, which was markedly attenuated by Akt inhibitor. C, Cell cycle modulation by Akt agonist in U251 cells with CLEC5A knockdown or inhibitor in U87 cells with CLEC5A overexpression, respectively. D, Cell migration modulation by Akt agonist in U251 cells with CLEC5A knockdown or inhibitor in U87 cells with CLEC5A overexpression, respectively. E, Cell invasion modulation by Akt agonist in U251 cells with CLEC5A knockdown or inhibitor in U87 cells with CLEC5A overexpression, respectively. Values are expressed as means ± SD, *P < 0.05, **P < 0.01